Cyclin-Dependent Kinase Inhibitor p27

A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.

Also Known As:

CDK Inhibitor p27; CDKN1B Protein; CDKN4 Protein; Cyclin-Dependent Kinase Inhibitor 1B; p27 CDK Inhibitor; p27 Kip1 Protein; p27Kip1 Protein; CDK Inhibitor, p27; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor p27; Kip1 Protein, p27; p27, CDK Inhibitor

Pharmalogical Action Categories:

Protein Kinase Inhibitors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Cell Cycle Proteins: 812
    - Cyclin-Dependent Kinase Inhibitor Proteins: 17
      - Cyclin-Dependent Kinase Inhibitor p27: 456
  - Intracellular Signaling Peptides and Proteins: 32
    - Cyclin-Dependent Kinase Inhibitor Proteins: 17
      - Cyclin-Dependent Kinase Inhibitor p27: 456
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 1691
      - Cyclin-Dependent Kinase Inhibitor Proteins: 17
        Cyclin-Dependent Kinase Inhibitor p27: 456
- Peptides: 84029
  - Intracellular Signaling Peptides and Proteins: 32
    - Cyclin-Dependent Kinase Inhibitor Proteins: 17
      - Cyclin-Dependent Kinase Inhibitor p27: 456

N S Penneys Selected Research

N S Penneys Research Topics

Disease

Drug/Important Bio-Agent (IBA)